Atherosclerosis Is a Smooth Muscle Cell-Driven Tumor-Like Disease.

Pan H, Ho SE, Xue C, Cui J, Johanson QS, Sachs N, Ross LS, Li F, Solomon RA, Connolly ES Jr, Patel VI, Maegdefessel L, Zhang H, Reilly MP.Circulation. 2024 Apr 30. doi: 10.1161/CIRCULATIONAHA.123.067587.

Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition.

Ducommun S, Jannig PR, Cervenka I, Murgia M, Mittenbühler MJ, Chernogubova E, Dias JM, Jude B, Correia JC, Van Vranken JG, Ocana-Santero G, Porsmyr-Palmertz M, McCann Haworth S, Martínez-Redondo V, Liu Z, Carlström M, Mann M, Lanner JT, Teixeira AI, Maegdefessel L, Spiegelman BM, Ruas JL. Mol Metab. 2024 Apr. doi: 10.1016/j.molmet.2024.101912.

High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis.

Bashore AC, Yan H, Xue C, Zhu LY, Kim E, Mawson T, Coronel J, Chung A, Sachs N, Ho S, Ross LS, Kissner M, Passegué E, Bauer RC, Maegdefessel L, Li M, Reilly MP. Arterioscler Thromb Vasc Biol. 2024 Feb 22. doi: 10.1161/ATVBAHA.123.320524.

Suppression of IL-1β promotes beneficial accumulation of fibroblast-like cells in atherosclerotic plaques in clonal hematopoiesis.

Fidler TP, Dunbar A, Kim E, Hardaway B, Pauli J, Xue C, Abramowicz S, Xiao T, O'Connor K, Sachs N, Wang N, Maegdefessel L, Levine R, Reilly M, Tall AR. Nat Cardiovasc Res. 2024 Jan;3(1):60-75. doi: 10.1038/s44161-023-00405-9.

Noncoding RNAs in the Vasculature: Basic Mechanisms and Therapeutic Perspectives.

Maegdefessel L, Boon RA, Dimmeler S. Arterioscler Thromb Vasc Biol. 2024 Jan;44(1):3-6. doi: 10.1161/ATVBAHA.123.319564. 

Utilization of an Artery-on-a-Chip to Unravel Novel Regulators and Therapeutic Targets in Vascular Diseases.

Paloschi V, Pauli J, Winski G, Wu Z, Li Z, Botti L, Meucci S, Conti P, Rogowitz F, Glukha N, Hummel N, Busch A, Chernogubova E, Jin H, Sachs N, Eckstein HH, Dueck A, Boon RA, Bausch AR, Maegdefessel L. Adv Healthc Mater. 2023 Oct 5:e2302907. doi: 10.1002/adhm.202302907.

The circular RNA Ataxia Telangiectasia Mutated regulates oxidative stress in smooth muscle cells in expanding abdominal aortic aneurysms.

Fasolo F, Winski G, Li Z, Wu Z, Winter H, Ritzer J, Glukha N, Roy J, Hultgren R, Pauli J, Busch A, Sachs N, Knappich C, Eckstein HH, Boon RA, Paloschi V, Maegdefessel L. Mol Ther Nucleic Acids. 2023 Aug 17;33:848-865. doi: 10.1016/j.omtn.2023.08.017.

Apolipoprotein E (ApoE) Rescues the Contractile Smooth Muscle Cell Phenotype in Popliteal Artery Aneurysm Disease.

Pauli J, Reisenauer T, Winski G, Sachs N, Chernogubova E, Freytag H, Otto C, Reeps C, Eckstein HH, Scholz CJ, Maegdefessel L, Busch A. Biomolecules. 2023 Jul 4;13(7):1074. doi: 10.3390/biom13071074.

Targeting non-coding RNAs for novel treatment strategies in vascular diseases.

Winter H, Maegdefessel L. Eur Heart J. 2023 Jul 1;44(25):2267-2269. doi: 10.1093/eurheartj/ehad240.

Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression.

Winter H, Winski G, Busch A, Chernogubova E, Fasolo F, Wu Z, Bäcklund A, Khomtchouk BB, Van Booven DJ, Sachs N, Eckstein HH, Wittig I, Boon RA, Jin H, Maegdefessel L. Mol Ther. 2023 Jun 7;31(6):1775-1790. doi: 10.1016/j.ymthe.2023.04.020.

Endothelial microRNAs and long noncoding RNAs in cardiovascular ageing.

Bink DI, Pauli J, Maegdefessel L, Boon RA. Atherosclerosis. 2023 Jun;374:99-106. doi: 10.1016/j.atherosclerosis.2023.03.019.

Long non-coding RNAs at the crossroad of vascular smooth muscle cell phenotypic modulation in atherosclerosis and neointimal formation.

Fasolo F, Paloschi V, Maegdefessel L.Atherosclerosis. 2023 Jun;374:34-43. doi: 10.1016/j.atherosclerosis.2022.11.021.

Human Macrophage Long Intergenic Noncoding RNA, SIMALR, Suppresses Inflammatory Macrophage Apoptosis via NTN1 (Netrin-1).

Cynn E, Li DY, O'Reilly ME, Wang Y, Bashore AC, Jha A, Foulkes AS, Zhang H, Winter H, Maegdefessel L, Yan H, Li M, Ross L, Xue C, Reilly MP.Arterioscler Thromb Vasc Biol. 2023 Feb;43(2):286-299. doi: 10.1161/ATVBAHA.122.318353.

CXCR4 - a possible serum marker for risk stratification of abdominal aortic aneurysms.

Reutersberg B, Metschl S, Salvermoser M, Eckstein HH, Knappich C, Maegdefessel L, Jaroslav P, Busch A. Vasa. 2023 Mar. doi: 10.1024/0301-1526/a001049.

Long non-coding RNAs at the crossroad of vascular smooth muscle cell phenotypic modulation in atherosclerosis and neointimal formation.

Fasolo F, Paloschi V, Maegdefessel L.Atherosclerosis. 2023 Jun. doi: 10.1016/j.atherosclerosis.2022.11.021.

Changes in Endocan and Dermatan Sulfate Are Associated with Biomechanical Properties of Abdominal Aortic Wall during Aneurysm Expansion and Rupture.

Metschl S, Bruder L, Paloschi V, Jakob K, Reutersberg B, Reeps C, Maegdefessel L, Gee M, Eckstein HH, Pelisek J.Thromb Haemost. 2022 Sep. doi: 10.1055/a-1772-0574.

Downregulation of Erythrocyte miR-210 Induces Endothelial Dysfunction in Type 2 Diabetes.

Zhou Z, Collado A, Sun C, Tratsiakovich Y, Mahdi A, Winter H, Chernogubova E, Seime T, Narayanan S, Jiao T, Jin H, Alvarsson M, Zheng X, Yang J, Hedin U, Catrina SB, Maegdefessel L, Pernow J.Diabetes. 2022 Feb 1;71(2):285-297. doi: 10.2337/db21-0093.