2026
Perk Is Dispensable for Smooth Muscle Cell Phenotype Switching in Atherosclerosis.
Zhu LY, Xue C, Bashore AC, Cui J, Yao S, Sachs N, Wettich J, Coronel J, Garcia EJ, Khalid S, Saleheen D, Li M, Maegdefessel L, Reilly MP. Arterioscler Thromb Vasc Biol. 2026 May 14. doi: 10.1161/ATVBAHA.125.323869. Online ahead of print. PMID: 42131916
Atherosclerosis Profiling Reveals BHLHE40 as a Candidate Modulator of VSMC.
Ibikunle CO, Garcia EJ, Xue C, Kim E, Yan H, Coronel J, Zhu LY, Cui J, Chung A, Fries LE, Sachs N, Bauer RC, Maegdefessel L, Li M, Tall AR, Bashore AC, Reilly MP. Circ Res. 2026 May 13. doi: 10.1161/CIRCRESAHA.125.326821. Online ahead of print. PMID: 42125810
Female-Biased VSMC GRNs Predict MYH9 as Regulator of Fibrous Plaque Phenotype.
Perry RN, Lenert G, Benavente ED, Bölük A, Hernandez R, Ma L, Barbera N, Watts K, Mendoza VD, Örd T, Taipale M, Sachs N, Pauli J, Mokry M, de Kleijn DPV, de Winther MPJ, Mayr M, Maegdefessel L, Reue K, Kaikkonen MU, Björkegren JLM, den Ruijter HM, Civelek M.Circ Res. 2026 May 8;138(10):e326941. doi: 10.1161/CIRCRESAHA.125.326941. Epub 2026 Apr 15. PMID: 41983287
Exercise Reverses Mental Stress-Induced Vascular Inflammation and Builds Stress Resilience.
Meyer-Lindemann U, Borbil K, Schwab M, Moggio A, Shen R, Sharifi MA, Dang TA, Schories V, Rottenkolber R, Rapelius S, Hinterdobler J, Mauersberger C, von Scheidt M, Maegdefessel L, Wackerhage H, Köhler K, Berga-Švītiņa E, Vilne B, Hristov M, Weber C, Steffens S, McAlpine CS, Schunkert H, Kessler T, Sager HB.JACC Basic Transl Sci. 2026 Apr 21;11(5):101536. doi: 10.1016/j.jacbts.2026.101536. Online ahead of print. PMID: 42019321
Evans BR, Schulz J, Triantafyllidou V, Yerly A, Thakur M, Angliker N, Siegrist M, Jansen Y, Yan Y, Maas SL, Gold C, Farina FM, Bayer B, Bartelt A, Weber C, Wettich J, Maegdefessel L, Sachs N, Schindewolf M, Kotelis D, Noels H, Santovito D, van der Vorst EPC, Döring Y.Cardiovasc Res. 2026 Mar 16;122(2):195-213. doi: 10.1093/cvr/cvaf258. PMID: 41264461
Cell type-specific epigenetic regulatory circuitry of coronary artery disease loci.
Hecker D, Song X, Baumgarten N, Diagel A, Katsaouni N, Li L, Li S, Kumar Maji R, Behjati Ardakani F, Ma L, Li Z, Moggio A, Tews D, Sager H, Maegdefessel L, Wabitsch M, Björkegren JLM, Schunkert H, Chen Z, Schulz MH.Nat Commun. 2026 Mar 10;17(1):2367. doi: 10.1038/s41467-026-70216-6. PMID: 41807385
Atherosclerotic Fibrous Plaques in Women Present ECM Remodeling Linked to TGF-β.
Sakkers TR, Mili E, Winter H, Kapteijn D, Perry RN, Barbera N, Watts K, Dias IR, Meteva D, Wesseling M, Mol BM, de Borst GJ, de Kleijn DPV, van der Laan SW, Civelek M, White SJ, Maegdefessel L, Mayr M, Pasterkamp G, Mokry M, Benavente ED, den Ruijter HM.Circ Res. 2026 Feb 27;138(5):e327624. doi: 10.1161/CIRCRESAHA.125.327624. Epub 2026 Feb 5. PMID: 41641539
Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease.
von Scheidt M, Adkar SS, Krefting J, Hoermann G, Meggendorfer M, Bauer S, Mitchell S, Pugach I, Friess C, Ma A, Hao K, Steigerwald S, Wahle M, Kessler T, Schwab M, Voll F, Mokry M, Sofokleous C, Palm KCA, Bongiovanni D, Fleig J, Oldenbuettel L, Chen Z, Hecker JS, Bassermann F, Maegdefessel L, Graw M, Ruusalepp A, Hilgendorf I, Leuschner F, Sager HB, Heimlich JB, Koenig W, Cremer S, Leistner DM, Abplanalp WT, Dimmeler S, Zeiher AM, van der Laan SW, Pasterkamp G, Braun C, Jaiswal S, Kovacic JC, Kern W, Haferlach C, Mann M, Cassese S, Kastrati A, Haferlach T, Leeper NJ, Björkegren JLM, Schunkert H.Eur Heart J. 2026 Jan 24;47(4):453-469. doi: 10.1093/eurheartj/ehaf602. PMID: 40900105
Nuclear receptor co-factor TBL1X/TBL1XR1 T cell activity protects against atherosclerosis.
Cingir Koker S, Mhamane A, Geppert J, Shakir G, Guillamat-Prats R, Chen B, Katra P, Geiger M, Tsokanos FF, Wolff G, Szendrödi J, Rohm M, Daniel C, Maegdefessel L, Steffens S, Herzig S.Mol Metab. 2026 Feb;104:102318. doi: 10.1016/j.molmet.2026.102318. Epub 2026 Jan 13. PMID: 41539423
Thakur M, Quillard T, Angliker N, Siegrist M, Jansen Y, Yan Y, Wollenhaupt J, Goettsch C, Maegdefessel L, Sachs N, Schindewolf M, Kotelis D, Noels H, Döring Y.Acta Physiol (Oxf). 2026 Jan;242(1):e70146. doi: 10.1111/apha.70146. PMID: 41399911
2025
Pauli J, Garger D, Peymani F, Wettich J, Sachs N, Wirth J, Steiger K, Hillig C, Zhang H, Tabas I, Tall A, Li M, Reilly MP, Branzan D, Prokisch H, Menden MP, Maegdefessel L. Nat Commun. 2025 Dec 18;16(1):11282. doi: 10.1038/s41467-025-67679-4. PMID: 41413386
Mallén A, Rotllan N, Griñán R, Varela C, Bertolino E, Paloschi V, Maegdefessel L, Escolà-Gil JC, Aran JM, Sbraga F, Blasco-Lucas A, Torras J, Navarro E, Hueso M. Am J Physiol Cell Physiol. 2025 Nov 25. doi: 10.1152/ajpcell.00242.2025. Online ahead of print. PMID: 41289597
Evans BR, Schulz J, Triantafyllidou V, Yerly A, Thakur M, Angliker N, Siegrist M, Jansen Y, Yan Y, Maas SL, Gold C, Farina FM, Bayer B, Bartelt A, Weber C, Wettich J, Maegdefessel L, Sachs N, Schindewolf M, Kotelis D, Noels H, Santovito D, van der Vorst EPC, Döring Y.Cardiovasc Res. 2025 Nov 20:cvaf258. doi: 10.1093/cvr/cvaf258. Online ahead of print. PMID: 41264461
Mukherjee D, Larcher V, Winter H, Sachs N, Andriani F, Chiesa M, Perrucci GL, Rega S, Günther S, Kuenne C, Martin JC, Gu Y, Pelisek J, Fischer A, Peruzzo S, Pizzo E, Peterson KL, Dimmeler S, Maegdefessel L, Cattaneo P, Evans SM, Guimarães-Camboa N. Cardiovasc Res. 2025 Nov 20:cvaf201. doi: 10.1093/cvr/cvaf201. Online ahead of print. PMID: 41263385
Daoud F, Holmberg J, Winter H, Sachs N, Maegdefessel L, Albinsson S. J Mol Cell Cardiol Plus. 2025 Oct 5;14:100487. doi: 10.1016/j.jmccpl.2025.100487. eCollection 2025 Dec. PMID: 41246212
Zhou X, Kuenne C, Günther S, Wittig I, Güven B, Boutguetait D, Delgado Lagos F, Sachs N, Maegdefessel L, Müller OJ, Münch C, Offermanns S, Fleming I, Siragusa M. Circulation. 2025 Oct 29. doi: 10.1161/CIRCULATIONAHA.125.074889. Online ahead of print. PMID: 41159282
PRDM16 regulates smooth muscle cell identity and atherosclerotic plaque composition.
Tan JME, Cheng L, Calhoun RP, Weller AH, Drareni K, Fong S, Barbara E, Lim HW, Xue C, Winter H, Auguste G, Miller CL, Reilly MP, Maegdefessel L, Lutgens E, Seale P. Nat Cardiovasc Res. 2025 Nov;4(11):1573-1588. doi: 10.1038/s44161-025-00737-8. Epub 2025 Oct 17. PMID: 41107595
Integrated single-cell atlas of human atherosclerotic plaques.
Traeuble K, Munz M, Pauli J, Sachs N, Vafadarnejad E, Carrillo-Roa T, Maegdefessel L, Kastner P, Heinig M. Nat Commun. 2025 Sep 10;16(1):8255. doi: 10.1038/s41467-025-63202-x. PMID: 40931012
Sugar, stress, and the arterial wall: a metabolic link in aortic aneurysms.
Kirchhoff F, Maegdefessel L. Eur Heart J. 2025 Sep 5:ehaf586. doi: 10.1093/eurheartj/ehaf586. Online ahead of print. PMID: 40910371 No abstract available.
Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease.
von Scheidt M, Adkar SS, Krefting J, Hoermann G, Meggendorfer M, Bauer S, Mitchell S, Pugach I, Friess C, Ma A, Hao K, Steigerwald S, Wahle M, Kessler T, Schwab M, Voll F, Mokry M, Sofokleous C, Palm KCA, Bongiovanni D, Fleig J, Oldenbuettel L, Chen Z, Hecker JS, Bassermann F, Maegdefessel L, Graw M, Ruusalepp A, Hilgendorf I, Leuschner F, Sager HB, Heimlich JB, Koenig W, Cremer S, Leistner DM, Abplanalp WT, Dimmeler S, Zeiher AM, van der Laan SW, Pasterkamp G, Braun C, Jaiswal S, Kovacic JC, Kern W, Haferlach C, Mann M, Cassese S, Kastrati A, Haferlach T, Leeper NJ, Björkegren JLM, Schunkert H.Eur Heart J. 2025 Sep 3:ehaf602. doi: 10.1093/eurheartj/ehaf602. Online ahead of print. PMID: 40900105
Circulating Trimethylamine N-Oxide and Growth Rate of Abdominal Aortic Aneurysms and Surgical Risk.
Cameron SJ, Li XS, Benson TW, Conrad KA, Wang Z, Fleifil S, Maegdefessel L, Mani K, Björck M, Scalise A, Pham M, Shim S, Wanhainen A, Sharew B, Tian MY, Wu Y, Lusis AJ, Lyden SP, Tang WHW, Owens AP 3rd, Hazen SL.JAMA Cardiol. 2025 Oct 1;10(10):1000-1009. doi: 10.1001/jamacardio.2025.2698. PMID: 40833686
Haase L, Belkacemi A, Neises L, Kiweler N, Wesely C, Huchzermeier R, Bozic M, Khakdan A, Sánchez M, Mary A, Sachs N, Winter H, Glaab E, Heneka MT, van der Vorst EP, Mittelbronn M, Meiser J, Schneider JG.J Clin Invest. 2025 Jun 12:e182472. doi: 10.1172/JCI182472.
Winski G, Chernogubova E, Busch A, Eken SM, Jin H, Lindquist Liljeqvist M, Khan T, Bäcklund A, Paloschi V, Roy J, Hultgren R, Brostjan C, de Borst GJ, Sluijter JPG, Sachs N, Eckstein HH, Boon RA, Spin JM, Tsao PS, Asselbergs FW, Maegdefessel L.Commun Med (Lond). 2025 Jun 6;5(1):218. doi: 10.1038/s43856-025-00892-w.
Nackenhorst MC, Menges F, Bohmann B, Zschäpitz D, Bollwein C, Flemming S, Sachs N, Eilenberg W, Brostjan C, Neumayer C, Trenner M, Ibing W, Schelzig H, Reeps C, Maegdefessel L, Regele H, Wagenhäuser MU, Scholz CJ, Gasser TC, Busch A.Cardiovasc Res. 2025 Apr 29:cvaf071. doi: 10.1093/cvr/cvaf071. Online ahead of print.
An atypical atherogenic chemokine that promotes advanced atherosclerosis and hepatic lipogenesis.
El Bounkari O, Zan C, Yang B, Ebert S, Wagner J, Bugar E, Kramer N, Bourilhon P, Kontos C, Zarwel M, Sinitski D, Milic J, Jansen Y, Kempf WE, Sachs N, Maegdefessel L, Ji H, Gokce O, Riols F, Haid M, Gerra S, Hoffmann A, Brandhofer M, Avdic M, Bucala R, Megens RTA, Willemsen N, Messerer D, Schulz C, Bartelt A, Harm T, Rath D, Döring Y, Gawaz M, Weber C, Kapurniotu A, Bernhagen J.Nat Commun. 2025 Mar 7;16(1):2297. doi: 10.1038/s41467-025-57540-z.
Parma L, Sachs N, Sobczak N, Li Z, Merchant K, Pauli J, Depuydt MAC, Wezel A, Smeets HJ, Bot I, Slütter B, Maegdefessel L, Weber C, Duchêne J, Megens RTA.Circulation. 2025 Feb 25;151(8):581-584. doi: 10.1161/CIRCULATIONAHA.124.072560. Epub 2025 Feb 24.
Ezh2 Shapes T Cell Plasticity to Drive Atherosclerosis.
Bonfiglio CA, Lacy M, Triantafyllidou V, Farina FM, Janjic A, Nitz K, Wu Y, Bazioti V, Avcilar-Kücükgöze I, Marques YFS, Joppich M, Kumkum M, Röß K, Venkatasubramani AV, Imhof A, Enard W, Maegdefessel L, de Winther M, Weber C, Santovito D, Lutgens E, Atzler D.Circulation. 2025 May 13;151(19):1391-1408. doi: 10.1161/CIRCULATIONAHA.124.072384. Epub 2025 Feb 7.
Circular RNAs increase during vascular cell differentiation and are biomarkers for vascular disease.
Northoff BH, Herbst A, Wenk C, Weindl L, Gäbel G, Brezski A, Zarnack K, Küpper A, Dimmeler S, Moretti A, Laugwitz KL, Engelhardt S, Maegdefessel L, Boon RA, Doppler S, Dreßen M, Lahm H, Lange R, Krane M, Krohn K, Kohlmaier A, Holdt LM, Teupser D.Cardiovasc Res. 2025 Apr 29;121(3):405-423. doi: 10.1093/cvr/cvaf013.
Long Non-Coding RNA Function in Smooth Muscle Cell Plasticity and Atherosclerosis.
Maegdefessel L, Fasolo F. Arterioscler Thromb Vasc Biol. 2025 Feb;45(2):172-185. doi: 10.1161/ATVBAHA.124.320393. Epub 2024 Dec 5, PMID: 39633574
2024
Long Non-Coding RNA Function in Smooth Muscle Cell Plasticity and Atherosclerosis.
Maegdefessel L, Fasolo F.Arterioscler Thromb Vasc Biol. 2025 Feb;45(2):172-185. doi: 10.1161/ATVBAHA.124.320393. Epub 2024 Dec 5.
Ticagrelor vs Prasugrel for Acute Coronary Syndrome in Routine Care.
Krüger N, Krefting J, Kessler T, Schmieder R, Starnecker F, Dutsch A, Graesser C, Meyer-Lindemann U, Storz T, Pugach I, Frieß C, Chen Z, Bongiovanni D, Manea I, Dreischulte T, Offenborn F, Krase P, Sager HB, Wiebe J, Kufner S, Xhepa E, Joner M, Trenkwalder T, Gueldener U, Kastrati A, Cassese S, Schunkert H, von Scheidt M; DigiMed Bayern Consortium.JAMA Netw Open. 2024 Dec 2;7(12):e2448389. doi: 10.1001/jamanetworkopen.2024.48389.
Liu W, Hardaway BD, Kim E, Pauli J, Wettich JL, Yalcinkaya M, Hsu CC, Xiao T, Reilly MP, Tabas I, Maegdefessel L, Schlepckow K, Haass C, Wang N, Tall AR.J Clin Invest. 2024 Nov 12;135(1):e182939. doi: 10.1172/JCI182939.
Kontidou E, Humoud R, Chernogubova E, Alvarsson M, Maegdefessel L, Collado A, Pernow J, Zhou Z.Am J Physiol Heart Circ Physiol. 2024 Nov 1;327(5):H1296-H1302. doi: 10.1152/ajpheart.00609.2024. Epub 2024 Oct 18.
Bamezai S, Zhang Y, Kumari M, Lotfi M, Alsaigh T, Luo L, Kumar GS, Wang F, Ye J, Puri M, Manchanda R, Paluri S, Adkar SS, Kojima Y, Ingelsson A, Bell CF, Lopez NG, Fu C, Choi RB, Miller Z, Barrios L, Walsh S, Ahmad F, Maegdefessel L, Smith BR, Leeper NJ.Nat Commun. 2024 Sep 13;15(1):8034. doi: 10.1038/s41467-024-52005-1.
Pourteymour S, Fan J, Majhi RK, Guo S, Sun X, Huang Z, Liu Y, Winter H, Bäcklund A, Skenteris NT, Chernogubova E, Werngren O, Li Z, Skogsberg J, Li Y, Matic L, Hedin U, Maegdefessel L, Ehrenborg E, Tian Y, Jin H.Cell Mol Life Sci. 2024 Aug 6;81(1):331. doi: 10.1007/s00018-024-05372-3.
Wang Y, Li G, Chen B, Shakir G, Volz M, van der Vorst EPC, Maas SL, Geiger M, Jethwa C, Bartelt A, Li Z, Wettich J, Sachs N, Maegdefessel L, Nazari Jahantigh M, Hristov M, Lacy M, Lutz B, Weber C, Herzig S, Guillamat Prats R, Steffens S.Cardiovasc Res. 2024 Oct 14;120(12):1411-1426. doi: 10.1093/cvr/cvae125.
Atherosclerosis Is a Smooth Muscle Cell-Driven Tumor-Like Disease.
Pan H, Ho SE, Xue C, Cui J, Johanson QS, Sachs N, Ross LS, Li F, Solomon RA, Connolly ES Jr, Patel VI, Maegdefessel L, Zhang H, Reilly MP.Circulation. 2024 Apr 30. doi: 10.1161/CIRCULATIONAHA.123.067587.
Ducommun S, Jannig PR, Cervenka I, Murgia M, Mittenbühler MJ, Chernogubova E, Dias JM, Jude B, Correia JC, Van Vranken JG, Ocana-Santero G, Porsmyr-Palmertz M, McCann Haworth S, Martínez-Redondo V, Liu Z, Carlström M, Mann M, Lanner JT, Teixeira AI, Maegdefessel L, Spiegelman BM, Ruas JL. Mol Metab. 2024 Apr. doi: 10.1016/j.molmet.2024.101912.
High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis.
Bashore AC, Yan H, Xue C, Zhu LY, Kim E, Mawson T, Coronel J, Chung A, Sachs N, Ho S, Ross LS, Kissner M, Passegué E, Bauer RC, Maegdefessel L, Li M, Reilly MP. Arterioscler Thromb Vasc Biol. 2024 Feb 22. doi: 10.1161/ATVBAHA.123.320524.
Fidler TP, Dunbar A, Kim E, Hardaway B, Pauli J, Xue C, Abramowicz S, Xiao T, O'Connor K, Sachs N, Wang N, Maegdefessel L, Levine R, Reilly M, Tall AR. Nat Cardiovasc Res. 2024 Jan;3(1):60-75. doi: 10.1038/s44161-023-00405-9.
Noncoding RNAs in the Vasculature: Basic Mechanisms and Therapeutic Perspectives.
Maegdefessel L, Boon RA, Dimmeler S. Arterioscler Thromb Vasc Biol. 2024 Jan;44(1):3-6. doi: 10.1161/ATVBAHA.123.319564.
2023
Paloschi V, Pauli J, Winski G, Wu Z, Li Z, Botti L, Meucci S, Conti P, Rogowitz F, Glukha N, Hummel N, Busch A, Chernogubova E, Jin H, Sachs N, Eckstein HH, Dueck A, Boon RA, Bausch AR, Maegdefessel L. Adv Healthc Mater. 2023 Oct 5:e2302907. doi: 10.1002/adhm.202302907.
Fasolo F, Winski G, Li Z, Wu Z, Winter H, Ritzer J, Glukha N, Roy J, Hultgren R, Pauli J, Busch A, Sachs N, Knappich C, Eckstein HH, Boon RA, Paloschi V, Maegdefessel L. Mol Ther Nucleic Acids. 2023 Aug 17;33:848-865. doi: 10.1016/j.omtn.2023.08.017.
Pauli J, Reisenauer T, Winski G, Sachs N, Chernogubova E, Freytag H, Otto C, Reeps C, Eckstein HH, Scholz CJ, Maegdefessel L, Busch A. Biomolecules. 2023 Jul 4;13(7):1074. doi: 10.3390/biom13071074.
Targeting non-coding RNAs for novel treatment strategies in vascular diseases.
Winter H, Maegdefessel L. Eur Heart J. 2023 Jul 1;44(25):2267-2269. doi: 10.1093/eurheartj/ehad240.
Winter H, Winski G, Busch A, Chernogubova E, Fasolo F, Wu Z, Bäcklund A, Khomtchouk BB, Van Booven DJ, Sachs N, Eckstein HH, Wittig I, Boon RA, Jin H, Maegdefessel L. Mol Ther. 2023 Jun 7;31(6):1775-1790. doi: 10.1016/j.ymthe.2023.04.020.
Endothelial microRNAs and long noncoding RNAs in cardiovascular ageing.
Bink DI, Pauli J, Maegdefessel L, Boon RA. Atherosclerosis. 2023 Jun;374:99-106. doi: 10.1016/j.atherosclerosis.2023.03.019.
Fasolo F, Paloschi V, Maegdefessel L.Atherosclerosis. 2023 Jun;374:34-43. doi: 10.1016/j.atherosclerosis.2022.11.021.
2022
Cynn E, Li DY, O'Reilly ME, Wang Y, Bashore AC, Jha A, Foulkes AS, Zhang H, Winter H, Maegdefessel L, Yan H, Li M, Ross L, Xue C, Reilly MP.Arterioscler Thromb Vasc Biol. 2023 Feb;43(2):286-299. doi: 10.1161/ATVBAHA.122.318353.
CXCR4 - a possible serum marker for risk stratification of abdominal aortic aneurysms.
Reutersberg B, Metschl S, Salvermoser M, Eckstein HH, Knappich C, Maegdefessel L, Jaroslav P, Busch A. Vasa. 2023 Mar. doi: 10.1024/0301-1526/a001049.
Fasolo F, Paloschi V, Maegdefessel L.Atherosclerosis. 2023 Jun. doi: 10.1016/j.atherosclerosis.2022.11.021.
Metschl S, Bruder L, Paloschi V, Jakob K, Reutersberg B, Reeps C, Maegdefessel L, Gee M, Eckstein HH, Pelisek J.Thromb Haemost. 2022 Sep. doi: 10.1055/a-1772-0574.
Downregulation of Erythrocyte miR-210 Induces Endothelial Dysfunction in Type 2 Diabetes.
Zhou Z, Collado A, Sun C, Tratsiakovich Y, Mahdi A, Winter H, Chernogubova E, Seime T, Narayanan S, Jiao T, Jin H, Alvarsson M, Zheng X, Yang J, Hedin U, Catrina SB, Maegdefessel L, Pernow J.Diabetes. 2022 Feb 1;71(2):285-297. doi: 10.2337/db21-0093.